Endocrine Abstracts

Thyroid autoimmunity and BC are strongly related, but the cause of this association is unknown. In BC an increase of lymphoid cell infiltrates may be detected very early during tumor development. BC cells share some antigenic properties similar to those detected in thyroid tissue, as NIS and peroxidase activity and it is possible that in patients with BC and thyroid autoimmunity, should be present serum immunoglobulins reacting with these specific antigenes.<p class="abste...

Recent in situ hybridization data showed high content of IGF-II mRNA in the stroma of breast cancer. The aim of this study was to examine the expression of IGF-II protein and its relationship with several prognostic parameters in 75 ductal infiltrating carcinoma (DIC) of the breast.The tissue sections were evaluated for IGF II protein, proliferating activity, ER, PR, p53, P21 oncogene expression using immunohistochemical procedures. The amoumt of ...

Whether TTA affects GO remains to be established. Here we studied the effects of TTA in 90 patients with mild-moderate GO randomized into 3 groups of thyroid treatment: MMI (methimazole), TX [near-total thyroidectomy (NTTX)], TTA (NTTX plus 131-I). Patients were treated with ivGC and evaluated at 3 and 9 mo. GO was considered improved or worsened when at least 2 of the following criteria changed, either positively or negatively: i) proptosis and/or eyelid width by at least 2 m...

Background/aims: Prostatic specific antigen (PSA) is the best prostatic tumor marker in man; Recently PSA has been detected in a variety of tissues and fluids in women and is considered a marker of hyperandrogenism. However no precise information are avaible about the physiology of PSA in females. The goal of this study was to assess serum concentrations of PSA in healthy pre-menopausal women (healthy pre-menopausal group) and menopausal women (menopause group) and compare the...